Muscimol Powder

Description

Buy Muscimol Powder Online

Buy Muscimol powder online from reputable supplier. Muscimol is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent, selective agonist for the GABAA receptors and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity. This colorless or white solid is classified as an isoxazole. Muscimol is one of the many known magic mushrooms.

Muscimol is a structural analog of γ-amino butyric acid. It functions as a GABA-agonist: a positive analog of the natural transmitter, which can activate GABA receptors in the brain. Muscimol is an isoxazole derivative occurring naturally in the mushroom Amanita muscaria.

Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons. Soluble in water (10 mg/mL); soluble in 1 N Sodium hydroxide, ethanol, or methanol. GABAA receptor agonist.

Muscimol is one of the most widely used agonists in the investigation of ionotropic GABA receptors. It is a more potent agonist at GABAC receptors than at GABAA receptors. The agonist action of muscimol at GABAC receptors is not blocked by bicuculline but is sensitive to picrotoxinin.

Muscimol became a prototype substance for the design and development of a range of isoxazoles with varying activities on GABA systems. THIP (Gaboxadol) is a conformationally restricted analog of muscimol with analgesic and sleep-promoting properties.